Research

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Please refer the software as the doctoral thesis:

Hlavnička, J. (2018). Automated analysis of speech disorders in neurodegenerative diseases. Doctoral Thesis. Czech Technical University in Prague: Prague, Czech Republic.

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or as a software:

Hlavnička, J. (2023, May 20). Version (3.1). The Dysarthria Analyzer. Retrieved July 16, 2023, from www.dysan.cz.

Enhance the visual appeal of your research presentations with our carefully designed logo available in PNG, PDF, or SVG format and comprehensive graphic manual.

graphic_ manual.pdf logo_dysarthria_analyzer.zip
Selected papers
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2021

Rusz J, Hlavnicka J, Novotny M, Tykalova T, Pelletier A, Montplaisir J, Gagnon J-F, Dusek P, Galbiati A, Marelli S, Timm PC, Teigen LN, Janzen A, Habibi M, Stefani A, Holzknecht E, Seppi K, Evangelista E, Rassu AL, Dauvilliers Y, Hogl B, Oertel W, St Louis EK, Ferini-Strambi L, Ruzicka E, Postuma RB, Sonka K. Speech biomarkers in rapid eye movement sleep behaviour disorder and Parkinson’s disease. Ann Neurol 2021; 90:62-75.

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2020

J. Hlavnička, T. Tykalová, O. Ulmanová, P. Dušek, D. Horáková, J. Klempíř, and J. Rusz. (2020). “Characterizing vocal tremor in progressive neurological diseases via automated acoustic analyses,” Clinical Neurophysiology, 131(5 May): 1155-1165. [Editorial]

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2019

Rusz J, Hlavnicka J, Novotny M, Tykalova T, J. Hlavnička, R. Čmejla, J. Klempíř, E. Růžička, and J. Rusz. (2019).”Acoustic tracking of pitch, modal and subharmonic vibrations of vocal folds in Parkinson’s disease and Parkinsonism,” IEEE Access, 7(December): 150339-150354.

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2017

J. Hlavnička, R. Čmejla, T. Tykalová, K. Šonka, E. Růžička, and J. Rusz (2017). “Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder,” Scientific Reports, 7(February): 12.

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2016

J. Rusz, J. Hlavnička, T. Tykalová, J. Bušková, O. Ulmanová, E. Růžička and K. Šonka. (2016). “Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder,” Sleep Medicine, 19(3 March): 141-147.

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2015

Rusz, J. Hlavnička, R. Čmejla, and E. Růžička. (2015). “Automatic evaluation of speech rhythm instability and acceleration in dysarthrias associated with basal ganglia dysfunction,” Frontiers in Bioengineering and Biotechnology, 3(July):104.

All related publications
(total of 68 peer-reviewed papers)
Year Published
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2023

Cmejla R, Novotny M, Rusz J, Tykalova T, Vimr J, Hlavnicka J. The automated screening of speech motor development in children based on the sequential motion rate. Comp Biol Med 2023; 162:107086.

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2023

Illner V, Tykalova T, Skrabal D, Klempir J, Rusz J. Automated Vowel Articulation Analysis in Connected Speech Among Progressive Neurological Diseases, Dysarthria Types, and Dysarthria Severities. J Speech Lang Hear Res 2023; in press.

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2023

Kouba T, Frank W, Tykalova T, Mühlbäck A, Klempíř J, Lindenberg KS, Landwehrmeyer GB, Rusz J. Speech biomarkers in Huntington disease: a cross-sectional study in pre-symptomatic, prodromal and early manifest stages. Eur J Neurol 2023;30:1262-1271.

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2023

Novotny M, Cmejla R, Tykalova T. Automated prediction of children's age from voice acoustics. Biomed Signal Process Control 2023;81:104490.

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2023

Rusz J, Krupicka E, Viteckova S, Tykalova T, Novotny M, Novak J, Dusek P, Ruzicka E. Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease. CNS Neurosci Rehab 2023; in press.

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2022

Illner V, Tykalova T, Novotny M, Klempir J, Dusek P, Rusz J. Towards automated articulation rate analysis via connected speech in dysarthrias. J Speech Lang Hear Res; 2022;65:1386-1401.

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2022

Kouba T, Illner V, Rusz J. Study protocol for using a smartphone application to investigate speech biomarkers of Parkinson’s disease and other synucleinopathies: SMARTSPEECH. BMJ Open 2022; 12:e059871.

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2022

Novotny M, Tykalova T, Ruzickova H, Ruzicka E, Dusek P, Rusz J. Automated video-based assessment of facial bradykinesia in de-novo Parkinson’s disease. NPJ Dig Med 2022;98.

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2022

Rusz J, Janzen A, Tykalova T, Novotny M, Zogala D, Timmermann L, Růžička E, Šonka K, Dušek P, Oertel W. Dysprosody in Isolated REM Sleep Behavior Disorder with Impaired Olfaction but Intact Nigrostriatal Pathway. Mov Disord 2022; 37:619-623.

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2022

Rusz J, Tykalova T, Novotny M, Zogala D, Růžička E, Dušek P. Automated speech analysis in early untreated Parkinson’s disease: relation to gender and dopaminergic transporter imaging. Eur J Neurol 2022; 29:81-90.

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2022

Subert M, Simek M, Novotny M, Tykalova T, Bezdicek O, Ruzicka E, Sonka K, Dusek P, Rusz J. Linguistic abnormalities in isolated rapid eye movement sleep behavior disorder. Mov Disord 2022; in press.

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2022

Svoboda E, Boril T, Rusz J, Tykalova T, Horakova D, Guttmann CRG, Blagoev KB, Hatabu H, Valtchinov VI. Assessing clinical utility of machine learning and artificial intelligence approaches to analyze speech recordings in multiple sclerosis: A pilot study. Comp Biol Med 2022;148:105853.

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2022

Tykalova T, Novotny M, Ruzicka E, Dusek P, Rusz J. Short-term effect of dopaminergic medication on speech in early-stage Parkinson’s disease. NPJ Parkinsons Dis 2022; 8:22.

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2021

Kryze P, Tykalova T, Ruzicka E, Rusz J. Effect of reading passage length on quantitative acoustic speech assessment in Czech-speaking individuals with Parkinson’s disease treated with subthalamic nucleus deep brain stimulation. J Acoust Soc Am 2021;3366-3374.

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2021

Miglis MG, Adler CH, Antelmi E, Arnaldi D, Baldelli L, Boeve BF, Cesari M, Dall’Antonia I, Diederich NJ, Doppler K, Dušek P, Ferri R, Gagnon J-F, Gan-Or Z, Hermann W, Högl B, Hu MT, Iranzo A, Janzen A, Kuzkina A, Lee J-Y, Leenders KL, Lewis SJG, Liguori C, Liu J, Lo C, Ehgoetz Martens KA, Nepozitek J, Plazzi G, Provini F, Puligheddu M, Rolinski M, Rusz J, Stefani A, Summers RLS, Yoo D, Zitser J, Oertel WH. Biomarkers of conversion to alpha-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder. Lancet Neurol 2021;20:671-684.

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2021

Rusz J, Hlavnicka J, Novotny M, Tykalova T, Pelletier A, Montplaisir J, Gagnon J-F, Dusek P, Galbiati A, Marelli S, Timm PC, Teigen LN, Janzen A, Habibi M, Stefani A, Holzknecht E, Seppi K, Evangelista E, Rassu AL, Dauvilliers Y, Hogl B, Oertel W, St Louis EK, Ferini-Strambi L, Ruzicka E, Postuma RB, Sonka K. Speech biomarkers in rapid eye movement sleep behaviour disorder and Parkinson’s disease. Ann Neurol 2021; 90:62-75.

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2021

Rusz J, Svihlik J, Kryze P, Novotny M, Tykalova T. Reproducibility of Voice Analysis with Machine Learning. Mov Disord 2021; 36:1282-1283.

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2021

Rusz J, Tykalova T, Novotny M, Růžička E, Dušek P. Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson’s disease. NPJ Parkinsons Dis 2021; 7:98.

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2021

Rusz J, Tykalova T, Novotny M, Zogala D, Šonka K, Růžička E, Dušek P. Defining speech subtypes in de novo Parkinson’s disease: response to long-term levodopa therapy. Neurology 2021; 97:e2124-e2135.

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2021

Rusz J, Tykalova T, Ramig LO, Tripoliti E. Guidelines for speech recording and acoustic analyses in dysarthrias of movement disorders. Mov Disord 2021; 36:230-238.

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2021

Rusz J, Tykalova T, Ramig LO, Tripoliti E. Reply to: “Fostering Voice Objective Analysis in Patients With Movement Disorders”. Mov Disord 2021; 36:1042-1043.

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2021

Rusz J, Tykalova T. Does Cognitive Impairment Influence Motor Speech Performance in De Novo Parkinson’s Disease? Mov Disord 2021; 36:2980-2982.

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2021

T. Tykalová, D. Škrabal, T. Bořil, R. Čmejla, J. Volín, and J. Rusz. Effect of aging on acoustic characteristics of voice pitch and formants in Czech vowels,” Journal of Voice 2021; 931.e21-931.e33.

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2021

Vasquez-Correa JC, Rios-Urrego CD, Arias-Vergara T, Schuster M, Rusz J, Nöth E, Orozco-Arroyave JR. Transfer Learning Helps to Improve the Accuracy to Classify Patients with Different Speech Disorders in Different Languages. Pattern Recognit Lett 2021; 150:272-279.

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2021

Šimek M, Rusz J. Validation of cepstral peak prominence in assessing early voice changes of Parkinson’s disease: effect of speaking task and ambient noise. J Acoust Soc Am 2021; 150:4522-4533.

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2020

D. Škrabal, T. Tykalová, J. Klempíř, E. Růžička, and J. Rusz. (2020). “Dysarthria enhancement mechanism under external clear speech instruction in Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy,” Journal of Neural Transmission, 127 (6 June): 905-914.

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2020

E. Eyigoz, M. Courson, L. Sedeno, K. Rogg, J.R. Orozco-Arroyave, E. Noth, S. Skodda, N. Trujillo, M. Rodriguez, J. Rusz, E. Munoz, J.F. Cardona, E. Herrera, E. Hesse, A. Ibanez, G. Cecchi, A.M. Garcia. (2020). “From discourse to pathology: Automatic identification of Parkinson’s disease patients via morphological measures across three languages,” Cortex, 132 (November): 191-205.

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2020

J. Hanuška, P. Dušek, J. Rusz, O. Ulmanová, A. Burgetová, and E. Růžička. (2020). “Eye movement abnormalities are associated with brainstem atrophy in Wilson disease,” Neurological Sciences, 41(5 May): 1097-1103.

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2020

J. Hlavnička, T. Tykalová, O. Ulmanová, P. Dušek, D. Horáková, J. Klempíř, and J. Rusz. (2020). “Characterizing vocal tremor in progressive neurological diseases via automated acoustic analyses,” Clinical Neurophysiology, 131(5 May): 1155-1165. [Editorial]

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2020

J. Rusz, and T. Tykalová. (2020). “Reader response: Motor speech patterns in Huntington disease,” Neurology, 95 (13 September).

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2020

K. Rozenstoks, M. Novotný, D. Horáková, and J. Rusz. (2020).”Automated assessment of oral diadochokinesis in multiple sclerosis using a neural network approach: effect of different syllable repetition paradigms,” IEEE Transactions on Neural Systems and Rehabilitation Engineering, 28(January): 32-41.

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2020

M. Novotny, J. Melechovsky, K. Rozenstoks, T. Tykalova, P. Kryze, M. Kanok, J. Klempir, and J. Rusz. (2020). “Comparison of Automated Acoustic Methods for Oral Diadochokinesis Assessment in Amyotrophic Lateral Sclerosis,” Journal of Speech, Language and Hearing Research, 63 (10 November): 3453-3460.

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2020

M. Novotný, P. Dušek, I. Daly, E. Růžička, J.Rusz. (2020).”Glottal Source Analysis of Voice Deficits in Newly Diagnosed Drug-naive Patients with Parkinson’s Disease: Correlation Between Acoustic Speech Characteristics and Non-Speech Motor Performance,” Biomedical Signal Processing and Control, 57(March): 101818.

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2020

T. Tykalová, J. Rusz, J. Švihlík. S. Bancone, A. Spezia, and M. T. Pellecchia. (2020). “Speech disorder and vocal tremor in postural instability/gait difficulty and tremor dominant subtypes of Parkinson’s disease,” Journal of Neural Transmission, 127 (9 September): 1295-1304.

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2020

V. Illner, P. Sovka, and J.Rusz. (2020). “Validation of freely-available pitch detection algorithms across various noise levels in assessing speech captured by smartphone in Parkinson’s disease,” Biomedical Signal Processing and Control, 58(April): 101831.

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2019

J. Hlavnička, R. Čmejla, J. Klempíř, E. Růžička, and J. Rusz. (2019).”Acoustic tracking of pitch, modal and subharmonic vibrations of vocal folds in Parkinson’s disease and Parkinsonism,” IEEE Access, 7(December): 150339-150354.

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2019

J. Rusz, A. Fečíková, T. Tykalová, R. Jech. (2019). “Effect of pallidal deep-brain stimulation on articulation rate in dystonia,” Neurological Sciences, 40(April): 869–873.

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2019

J. Rusz, M. Vaněčková, B. Beňová, T. Tykalová, M. Novotný, H. Růžičková, T. Uher, M. Andělová, K. Novotná, L. Friedová, J. Motýl, K. Kučerová, J. Krásenský, D. Horáková. (2019). “Brain volumetric correlates of dysarthria in multiple sclerosis,” Brain and Language, 194(7 July): 58-64.

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2019

J. Rusz, T. Tykalová, G. Salerno, S. Bancone, J. Scarpelli, M. T. Pellecchia. (2019). “Distinctive speech signature in cerebellar and parkinsonian subtypes of multiple system atrophy,” Journal of Neurology, 266(6 June): 1394-1404.

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2019

L. Friedová, J. Rusz, J. Motýl, B. Srpová, K. Vodehnalová, M. Andělová, K. Novotná, M. Novotný, H. Růžičková, T. Tykalová, E. Kubala Havrdová, D. Horáková, and T. Uher. (2019). “Slowed articulation rate is associated with information processing speed decline in multiple sclerosis: A pilot study,” Journal of Clinical Neuroscience, 65(7 July): 28-33.

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2019

L. Moro-Velazquez, J. A. Gomez-Garcia, J. I. Godino-Llorente, J. Villalba, J. Rusz, S. Shattuck-Hufnagel, N. Dehak. (2019). “A forced gaussians based methodology for the differential evaluation on Parkinson’s disease by means of speech processing,” Biomedical Signal Processing and Control (February), 48: 205-220.

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2018

J. Rusz, B. Beňová, H. Růžičková, M. Novotný, T. Tykalová, J. Hlavnička, T. Uher, M. Vaněčková, M. Andělová, K. Novotná, L. Kadrnožková, and D. Horáková. (2018). “Characteristics of motor speech phenotypes in multiple sclerosis,” Multiple Sclerosis and Related Disorders, 19(1 January): 62-69.

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2018

J. Rusz, J. Hlavnička, T. Tykalová, M. Novotný, P. Dušek, K. Šonka, and E. Růžička. (2018). “Smartphone allows capture of speech abnormalities associated with high risk of developing Parkinson’s disease,” IEEE Transactions on Neural Systems and Rehabilitation Engineering, 26(8 August): 1495-1507.

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2018

J. Rusz, T. Tykalová, A. Fečíková, D. Šťastná, D. Urgošík, R. Jech. (2018). “Dualistic effect of pallidal deep brain stimulation on motor speech disorders in dystonia,” Brain Stimulation, 11(4 July-August): 896-903.

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2018

M. Skorvanek, E. Feketeova, M. M. Kurtis, J. Rusz, and K. Šonka. (2018). “Accuracy of rating scales and clinical measures for screening of rapid eye movement sleep behavior disorder and for predicting conversion to Parkinson’s disease and other synucleinopathies,” Frontiers in Neurology, 9(May): 376.

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2017

J. Hlavnička, R. Čmejla, T. Tykalová, K. Šonka, E. Růžička, and J. Rusz (2017). “Automated analysis of connected speech reveals early biomarkers of Parkinson’s disease in patients with rapid eye movement sleep behaviour disorder,” Scientific Reports, 7(February): 12.

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2017

J. Rusz, M. Novotný, J. Hlavnička, T. Tykalová, and E. Růžička. (2017). High-accuracy voice-based classification between patients with Parkinson’s disease and other neurological diseases may be an easy task with inappropriate experimental design. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 25(8 August): 1319-1321.

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2017

T. Tykalová, J. Rusz, J. Klempíř, R. Čmejla, and E. Růžička. (2017). “Distinct patterns of consonant articulation among Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy,” Brain and Language, 165(2 February): 1-9.

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2016

J. Rusz, J. Hlavnička, T. Tykalová, J. Bušková, O. Ulmanová, E. Růžička and K. Šonka. (2016). “Quantitative assessment of motor speech abnormalities in idiopathic rapid eye movement sleep behaviour disorder,” Sleep Medicine, 19(3 March): 141-147.

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2016

J. Rusz, T. Tykalová, J. Klempíř, R. Čmejla, and E. Růžička. (2016). “Effects of dopaminergic replacement therapy on motor speech disorders in Parkinson’s disease: a longitudinal follow-up study on previously untreated patients,” Journal of Neural Transmission, 123(4 April): 379-387.

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2016

J.R. Orozco-Arroyave, F. Honig, J.D. Arias-Londono, J.F. Vargas-Bonilla, K. Daqrouq, S. Skodda, J. Rusz, and E. Noth. (2016). “Automatic detection of Parkinson’s disease in running speech spoken in three different languages,” Journal of the Acoustical Society of America, 139(1 January): 481-500.

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2016

M. Novotný, J. Rusz, R. Čmejla, H. Růžičková, J. Klempíř, and E. Růžička. (2016). “Hypernasality associated with basal ganglia dysfunction: evidence from Parkinson’s disease and Huntington’s disease,” PeerJ, 4(September): 2530. [suppl. material]

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2016

T. Tykalová, M. Pospíšilová, R. Čmejla, J. Jeřábek, P. Mareš, J. Rusz. (2016). “Speech changes after coordinative training in patients with cerebellar ataxia: A pilot study,” Neurological Sciences, 37(2 February): 293-296.

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2015

J. Rusz, C. Bonnet, J. Klempíř, T. Tykalová, E. Baborová, M. Novotný, A. Rulseh, and E. Růžička. (2015). “Speech disorders reflect differing pathophysiology in Parkinson’s disease, progressive supranuclear palsy and multiple system atrophy,” Journal of Neurology, 262(4 April): 992-1001.

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2015

J. Rusz, J. Hlavnička, R. Čmejla, and E. Růžička. (2015). “Automatic evaluation of speech rhythm instability and acceleration in dysarthrias associated with basal ganglia dysfunction,” Frontiers in Bioengineering and Biotechnology, 3(July):104.

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2015

J.R. Orozco-Arroyave, E.A. Belalcazar-Bolanos, J.D. Arias-Londono, J.F. Vargas-Bonilla, S. Skodda, J. Rusz, K. Daqrouq, F. Honig, and E. Noth. (2015). “Characterization Methods for the Detection of Multiple Voice Disorders: Neurological, Functional, and Laryngeal Diseases,” IEEE Journal of Biomedical and Health Informatics, 19(6 November): 1820-1828.

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2015

T. Tykalová, J. Rusz, R. Čmejla, J. Klempíř, H. Růžičková, J. Roth, and E. Růžička. (2015). “Effect of dopaminergic medication on speech dysfluency in Parkinson’s disease: a longitudinal study,” Journal of Neural Transmission, 122(8 August): 1135-1142.

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2014

J. Rusz, C. Saft, U. Schlegel, R. Hoffman, S. Skodda. (2014). “Phonatory Dysfunction as a Preclinical Symptom of Huntington Disease,” PLoS One, 9(11 November): e113412.

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2014

J. Rusz, J. Klempíř, T. Tykalová, E. Baborová, R. Čmejla, E. Růžička, and J. Roth. (2014). “Characteristics and occurrence of speech impairment in Huntington’s disease: possible influence of antipsychotic medication,” Journal of Neural Transmission, 121(12 December): 655-664.

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2014

J. Rusz, M. Megrelishvili, C. Bonnet, M. Okujava, H. Brožová, I. Khatiashvili, M. Sekhniashvili, M. Janelidze, E. Tolosa, E. Růžička. (2014). “A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse,” Journal of Neural Transmission, 121(6 June): 655-664.

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2014

M. Novotný, J. Rusz, R. Čmejla, E. Růžička. (2014). Automatic evaluation of articulatory disorders in Parkinson’s disease. IEEE/ACM Transactions on Audio, Speech, and Language Processing, 22(9 September): 1366-1378.

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2014

T. Tykalová, J. Rusz, R. Čmejla, H. Růžičková, and E. Růžička. (2014). “Acoustic Investigation of Stress Patterns in Parkinson’s Disease,” Journal of Voice, 28(1 January): 129.e1-129.e8.

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2013

J. Rusz, J. Klempíř, E. Baborová, T. Tykalová, V. Majerová, R. Čmejla, E. Růžička, and J. Roth. (2013). “Objective Acoustic Quantification of Phonatory Dysfunction in Huntington’s Disease,” PLoS One, 8(6 June): e65881.

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2013

J. Rusz, R. Čmejla, H. Ružičková, J. Klempíř, V. Majerová, J. Picmausová, J. Roth, and E. Růžička. (2013). “Evaluation of speech impairment in early stages of Parkinson’s disease: a prospective study with the role of pharmacotherapy,” Journal of Neural Transmission, 120(2 February): 319-329.

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2013

J. Rusz, R. Čmejla, T. Tykalová, H. Ružičková, Jiří Klempíř, Veronika Majerová, Jana Picmausová, Jan Roth, and E. Růžička. (2013). “Imprecise vowel articulation as a potential early marker of Parkinson’s disease: Effect of speaking task,” Journal of the Acoustical Society of America, 134(3 October): 2171-2181.

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2013

R. Čmejla, J. Rusz, P. Bergl, and J. Vokřál. (2013). Bayesian changepoint detection for the automatic assessment of fluency and articulatory disorders. Speech Communication, 55(1 January): 178-189. [suppl. material]

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2011

J. Rusz, R. Čmejla, H. Ružičková, J. Klempíř, V. Majerová, J. Picmausová, J. Roth, and E. Růžička. (2011). “Acoustic assessment of voice and speech disorders in Parkinson’s disease through quick vocal test,” Movement Disorders, 26(10): 1951-1952. [suppl. material]

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2011

J. Rusz, R. Čmejla, H. Ružičková, and E. Růžička. (2011). “Quantitative acoustic measurements for characterization of speech and voice disorders in early untreated Parkinson’s disease,” Journal of the Acoustical Society of America, 129(1): 350-367.

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